Author Archives: WeimerMicroLab

Streptococcus might provoke colon cancer

Contributed by Nguyet Kong In a recent PLOS paper, researchers from Texas A&M found a bacterium, Streptococcus gallolyticus might lead to colon cancer by assisting with tumor growth that might cause more cancer-related deaths. Streptococcus has been known that there is an association with cancer, but little is known about Streptococcus role in that association. […]

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Herpesvirus Latency Bacterial Protection

Contributed by Azarene Foutouhi Herpesviridae is a large family of Herpesviruses which are named for their tendency to result in recurrent infections. After clearance of lytic infections, these viruses enter latency, a mechanism which allows them to resist elimination and establish recurrent lifelong infections. More than 90% of people have become infected with one of […]

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Cancer cells restructure genomes to reproduce more easily

Contributed by Nguyet Kong A group at Stowers Institute in Kansas City recently published their study in PLos Genetics describing that cancer cells restructuring in the ribosomal DNA to more easily reproduce copies. The rDNA cellular functions include regulating gene expression, chromosome organization, and chromatin factors. There not much known about the stability of rDNA, […]

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Climate Change and the Microbiome

Contributed by Azarene Foutouhi While the ecological implications of climate change are well established, recent studies have pointed to changes in the microbiome as a casualty of the warming Earth. Studies testing the effects of temperature changes on the gut microbiomes of ectotherms such as lizards, temperature increases resulted in significant changes in microbiome composition. […]

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Salmonella lysozyme activity is central for bacterial pathogenesis

  Contributed by Narine Arabyan Lysozyme hydrolyzes the β-1,4-glycosidic bond of oligosaccharides. These enzymes are part of a broad group of glycosyl hydrolases that are poorly characterized. Lysozyme enzymes belong to the GH24 family of glycosyl hydrolases (GHs)1. GHs play an important role during infection by altering the host glycan structure to gain access of […]

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PCR

Contributed by Ning Chin Polymerase Chain Reaction (PCR) is one of the most important technique in the field of molecular biology. The idea of PCR came to Kary Mullis in 1983 when he was driving from Berkeley to Mendocino. 34 years later, PCR technique is used heavily and taught to students as a basic molecular […]

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Herpesvirus Latency Confers Protection From L. monocytogenes and Y. pestis

Contributed by Azarene Foutouhi Susceptibility to bacterial infections depends on many things including the individual’s immunologic condition and the virulence of the bacteria. After preliminary data showed prolonged macrophage activation during gamma-Herpesvirus latency, researchers wondered if this state might be associated with resistance to infection. Mice five weeks post infection with HV68 or MCMV challenged […]

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